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This standard contributes to the following Sustainable Development Goals: 10 Reduced Inequalities 1 No Poverty 12 Responsible Consumption and Production 3 Good Health and Well-being 2 Zero Hunger 13 Climate Action 5 Gender Equality 15 Life on Land 7 Affordable and Clean Energy 6 Clean Water and Sanitation 9 Industry, Innovation and Infrastructure 8 Decent Work and Economic Growth Buy this standard en Format Language std 1 124 PDF + ePub English std 2 124 Paper English CHF124 Buy
Buy this standard Life cycle Previously Withdrawn ISO 9644:2008 Now Published ISO 9644:2018 Stage: 60.60 00 Preliminary 10 Proposal 10.99 2015-04-20 New project approved 20 Preparatory 30 Committee 30.00 2017-01-12 Committee draft (CD) registered 30.20 2017-01-17 CD study initiated 30.60 2017-03-16 Close of comment period 30.99 2017-04-05 CD approved for registration as DIS 40 Enquiry 40.00 2017-04-05 DIS registered 40.20 2017-06-29 DIS ballot initiated: 12 weeks 40.60 2017-09-21 Close of voting 40.99 2018-01-21 Full report circulated: DIS approved for registration as FDIS 50 Approval 50.00 2018-02-02 Final text received or FDIS registered for formal approval 50.20 2018-04-26 Proof sent to secretariat or FDIS ballot initiated: 8 weeks 50.60 2018-06-23 Close of voting. Proof returned by secretariat 60 Publication 60.00 2018-06-23 International Standard under publication 60.60 2018-08-16 International Standard published 90 Review 90.20 International Standard under systematic review 90.60 Close of review 95 Withdrawal Got a question?Check out our FAQs
Some spontaneous germline gain-of-function mutations promote spermatogonial stem cell clonal expansion and disproportionate variant sperm production leading to unexpectedly high transmission rates for some human genetic conditions. To measure the frequency and spatial distribution of de novo mutations we divided three testes into 192 pieces each and used error-corrected deep-sequencing on each piece. We focused on PTPN11 (HGNC:9644) Exon 3 that contains 30 different PTPN11 Noonan syndrome (NS) mutation sites. We found 14 of these variants formed clusters among the testes; one testis had 11 different variant clusters. The mutation frequencies of these different clusters were not correlated with their case-recurrence rates nor were case recurrence rates of PTPN11 variants correlated with their tyrosine phosphatase levels thereby confusing PTPN11's role in germline clonal expansion. Six of the PTPN11 exon 3 de novo variants associated with somatic mutation-induced sporadic cancers (but not NS) also formed testis clusters. Further, three of these six variants were observed among fetuses that underwent prenatal ultrasound screening for NS-like features. Mathematical modeling showed that germline selection can explain both the mutation clusters and the high incidence of NS (1/1000-1/2500).
Lin, J. N., Lin, H. Y., Yang, N. S., Li, Y. H., Lee, M. R., Chuang, C. H., . . . Way, T. D. (2013). Chemical Constituents and Anticancer Activity of Yellow Camellias against MDA-MB-231 Human Breast Cancer Cells. Journal of Agricultural and Food Chemistry, 61(40), 9638-9644. (IF:2.912)
Chalati, Wail, Crilly, Philip, Fletcher, John and Kayyali, Reem (2020) A comparative study of the cost and uptake of community pharmacy "stop smoking and emergency contraception" services from the perspective of the National Health Service. Journal of Research in Pharmacy Practice, 9(2), pp. 73-87. ISSN (print) 2319-9644 041b061a72